Shared pathways to infectious disease susceptibility?
نویسندگان
چکیده
منابع مشابه
Genetics of susceptibility to human infectious disease.
Before Robert Koch's work in the late nineteenth century, diseases such as tuberculosis and leprosy were widely believed to be inherited disorders. Heritability of susceptibility to several infectious diseases has been confirmed by studies in the twentieth century. Infectious diseases, old and new, continue to be an important cause of mortality worldwide. A greater understanding of disease proc...
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Psychological stress is known to affect immune function and to predict infectious disease susceptibility. However, not all individuals who are stressed develop disease. In the present article, we report on a series of studies from our laboratory describing interindividual variability of immune responses to psychological stress. In our initial series of experimental investigations, we demonstrat...
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BACKGROUND The interleukin-2-mediated immune response is critical for host defense against infectious pathogens. Cytokine-inducible SRC homology 2 (SH2) domain protein (CISH), a suppressor of cytokine signaling, controls interleukin-2 signaling. METHODS Using a case-control design, we tested for an association between CISH polymorphisms and susceptibility to major infectious diseases (bactere...
متن کاملPregnancy and Susceptibility to Infectious Diseases
To summarize the literature regarding susceptibility of pregnant women to infectious diseases and severity of resulting disease, we conducted a review using a PubMed search and other strategies. Studies were included if they reported information on infection risk or disease outcome in pregnant women. In all, 1454 abstracts were reviewed, and a total of 85 studies were included. Data were extrac...
متن کاملGenetics of Susceptibility to Infectious Diseases
W e and microbial pathogens are often locked inadynamicbattlemediated by their virulence factors and our defenses. If we do not mount effective immune responses to pathogens, we will not overcome infections. However, if we overreact, host immune cascades may make those infections more severe. Both nonspecific factors, such as age and general health status, as well as specific genetic factors co...
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ژورنال
عنوان ژورنال: Genome Medicine
سال: 2010
ISSN: 1756-994X
DOI: 10.1186/gm173